Development of Diagnostic Assays for Rapid Detection of Antibiotic Resistance

INTRODUCTION:

Antibiotic resistant bacteria are a rising public health threat . Antibiotic resistant bacteria cause complication of therapy of other diseases in many clinical branches (e.g., cardiology/cardiosurgery, intensive medicine, transplantology).

TECHNOLOGY (INVENTION) DESCRIPTION:

Development of Rapid Assays for Detection of Resistance Mechanisms based on MALDI-TOF MS

ADVANTAGES OVER EXISTING SOLUTIONS:

We developed a kit for functional detection of carbapenemases (the most danger resistance currently). All the assays are validated on our robust collection of resistant bacterial isolates (>1000)

DEVELOPMENT STATUS (STAGE):

We developed and patented an assay for detection of enzymes responsible for degradation of common antibiotics(β-lactams)

PUBLICATIONS:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3553667/

IP PROTECTION STATUS:

International Patent Application published under PCT on December 24, 2014

TECHNOLOGY / IP OWNERS :

Charles University