Light source with homogeneity of light field, primarily for induction and monitoring of photodynamic effect in vitro

INTRODUCTION:

Photodynamic therapy (PDT) is besides chemotherapy, radiotherapy and immunotherapy other option for treatment of tumor diseases. It is a kind of photochemotherapy that is characterized by a harmful effect of photodynamically active drug and light in the presence of oxygen molecules. The physical principle of PDT is energy or electron transfer from

TECHNOLOGY (INVENTION) DESCRIPTION:

The invention is in an arrangement of a light source with homogeneity of light fi eld, primarily for induction and monitoring of photodynamic effect in vitro, intended primarily for treatment tumor diseases via photodynamic therapy.

ADVANTAGES OVER EXISTING SOLUTIONS:

Light source with homogeneity of light fi eld, primarily for induction and monitoring of photodynamic effect in vitro consists of a body adapted for sample placing and a set of LED diodes. LEDs are mounted inside of the body and arranged in a circle around the sample minimally in one horizontal plane so that their light beams are focused on the sample. LED diodes are exchangeable.

DEVELOPMENT STATUS (STAGE):

Prototype. Validation protocols.

PUBLICATIONS:

Kolarova H, Bajgar R, Tomankova K, Krestyn E, Dolezal L, Halek J. In vitro study of reactive oxygen species production during photodynamic therapy in ultrasound-pretreated cancer cells. Physiological Research 2007; Volume 56, Pages S27-32. 2007. Krestyn E, Kolarova H, Bajgar R, Tomankova K. Photodynamic properties of ZnTPPS4, ClAlPcS2 and ALA in human melanoma G361 cells. Toxicology in Vitro, Volume 24, Issue 1, Pages 286-291, 2010.

IP PROTECTION STATUS:

Patents: CZ 302084 SK 288148

TECHNOLOGY / IP OWNERS :

Palacky University Olomouc - Institution of Molecular and Translational Medicine (IMTM), Faculty of Medicine and Dentistry