MEPIOR : Module for Electrophysiology Processing In Online Regime

INTRODUCTION:

Complex software for acquisition, processing and visualisation of data from intracranial EEG (electroencephalography) in real time for the purpose of precise localisation of epileptic tissue in the brain. Electroencephalography (EEG) is a method to record electrical activity of the brain. It measures voltage fluctuations resulting from ionic current within the neurons of the brain. EEG is used to diagnose epilepsy, disease which affects nearly 50 million people worldwide. It is also used to diagnose brain tumors, stroke, sleep disorders, brain damage, brain dysfunctions, inflammation of the brain, and depth of anesthesia, coma, or brain death. The software allows for more precise localisation of affected tissue in the brain and thus more effective treatment than any other method.

TECHNOLOGY (INVENTION) DESCRIPTION:

MEPIOR is the only software in the world that allows complex processing of high-frequency itracranial EEG to identify various modern biomarkers of epileptogenic tissue in the iEEG signal (interictal discharges, high-frequency oscillations, connectivity changes, etc.). The detection of these biomarkers allows rapid localization of seizure-generating tissue and can provide physicians with information and the current state of the patient's brain. The software also allows connection to any acquisition hardware that supports sending iEEG data over a data network. Due to the modular nature of the software, it can be easily extended with new algorithms for EEG processing. In principle, the software can also be used to process other electrophysiological signals, such as ECG or EMG.

ADVANTAGES OVER EXISTING SOLUTIONS:

Several companies have an online interictal discharge detector. However, the developed software is the only one in the world that allows complex processing of high-frequency itracranial EEG to identify various modern biomarkers of epileptogenic tissue in the iEEG signal (interictal discharges, high-frequency oscillations, connectivity changes, etc.). The software also allows connection to any acquisition hardware that supports sending iEEG data over a data network. Due to the modular nature of the software, it can be easily extended with new algorithms for EEG processing. In principle, the software can also be used to process other electrophysiological signals, such as ECG or EMG.

DEVELOPMENT STATUS (STAGE):

Fully developed, tested at 1st Neurilogical Department of St-. Anne´s University Hospital and at Mayo Clinic in the USA

PUBLICATIONS:

NREM sleep is the state of vigilance that best identifies the epileptogenic zone in the interictal electroencephalogram. Klimes P, Cimbalnik J, Brazdil M, Hall J, Dubeau F, Gotman J, Frauscher B. Epilepsia. 2019 Dec; Multi-feature localization of epileptic foci from interictal, intracranial EEG. Cimbalnik J, Klimes P, Sladky V, Nejedly P, Jurak P, Pail M, Roman R, Daniel P, Guragain H, Brinkmann B, Brazdil M, Worrell G. Clin Neurophysiol. 2019 Oct; Hippocampal high frequency oscillations in unilateral and bilateral mesial temporal lobe epilepsy. Řehulka P, Cimbálník J, Pail M, Chrastina J, Hermanová M, Brázdil M. Clin Neurophysiol. 2019 Jul

IP PROTECTION STATUS:

Copyright, BSD 3 licence.

TECHNOLOGY / IP OWNERS :

St. Anne´s University Hospital in Brno